Author: chris

You are a biomedical engineer working in the Research and Development Division of a company in the cardiovascular prostheses field. Your project is to design a blood compatible material for vascular prostheses.

a. What characteristics should this material have?

b. The implant must be designed to last for a minimum of 3 years in-vivo. There are 2 major mechanisms of chemical degradation of polymers in-vivo. Describe each of these mechanisms. Given the following polymers, indicate whether they are susceptible to hydrolysis, oxidation, both or neither of these processes.

Poly(carbonate urethane) Poly(ether urethane)
Poly(ethylene terephthalate) Polyethylene (linear)
Polytetrafluoroethylene

c. Choose one of these materials for your new heart valve material. Justify your choice.

d. Discuss the factors that influence cell adhesion to biomaterials surfaces.

e. How could you modify the surface of this material to improve its haemocompatibility?

You are a biomedical engineer working in the Research and Development Division of a company in the cardiovascular prostheses field. Your project is to design a blood compatible material for vascular prostheses.

a. What characteristics should this material have?

b. The implant must be designed to last for a minimum of 3 years in-vivo. There are 2 major mechanisms of chemical degradation of polymers in-vivo. Describe each of these mechanisms. Given the following polymers, indicate whether they are susceptible to hydrolysis, oxidation, both or neither of these processes.

Poly(carbonate urethane) Poly(ether urethane)
Poly(ethylene terephthalate) Polyethylene (linear)
Polytetrafluoroethylene

c. Choose one of these materials for your new heart valve material. Justify your choice.

d. Discuss the factors that influence cell adhesion to biomaterials surfaces.

e. How could you modify the surface of this material to improve its haemocompatibility?

You are a biomedical engineer working in the Research and Development Division of a company in the cardiovascular prostheses field. Your project is to design a blood compatible material for vascular prostheses.

a. What characteristics should this material have?

b. The implant must be designed to last for a minimum of 3 years in-vivo. There are 2 major mechanisms of chemical degradation of polymers in-vivo. Describe each of these mechanisms. Given the following polymers, indicate whether they are susceptible to hydrolysis, oxidation, both or neither of these processes.

Poly(carbonate urethane) Poly(ether urethane)
Poly(ethylene terephthalate) Polyethylene (linear)
Polytetrafluoroethylene

c. Choose one of these materials for your new heart valve material. Justify your choice.

d. Discuss the factors that influence cell adhesion to biomaterials surfaces.

e. How could you modify the surface of this material to improve its haemocompatibility?

Answer questions below about the metabolic map and additional resources(textbook ‘General, Organic and Biochemistry’ eighth edition and the internet. The number of sources do not matter. Questions just need to be answered from the sources that have the answer. Some questions may be easir to anser than others, but it also depends a lot on a particular pathway that is assigned. Gluconeogenesis was assigned to us. Youi should decide which questions are pertinent and most applicable to the assigned pathway.

Your paper should cover the following:

1) Where your pathway located in the cell and what is the main purpose of your pathway
2) Identification of your pathway as either linear, branched, cyclic or spinal
3)How your pathway fits into the overall scheme of metabolism.
4)The class of biomolecuses involved in your pathway (proteins, carbohydrates, lipids or nucleic acids.
5)Where your pathway might be located in an overall map of metabolism
6) Identification of your pathway as anabolic or catabolic.
7) Overall, does your pathway require energy or release energy?
8)Identification of the reactants, key intermediates, and final products in your pathway.
9)Identification of any acidic basic or fundamental groups in each of the reactants, key intermediates, and final products. Are they shown adjusted to pH 7.4? If not, how do u adjust them?
10) Identify any steps which involve phosphorylation/dephosphorylation reactions.
11) Identify any steps which involve hydration/dehydration reactons.
12)Identify any steps which involve hydrolysis reactions.
13) Identify any coupled reactions and what processes are coupled together. a)ocideation/reduction reactions: determine what is being oxidized and what is being reduced b) energy transfer: determine which is exergonic and which is endergonic.

Answer questions below about the metabolic map and additional resources(textbook ‘General, Organic and Biochemistry’ eighth edition and the internet. The number of sources do not matter. Questions just need to be answered from the sources that have the answer. Some questions may be easir to anser than others, but it also depends a lot on a particular pathway that is assigned. Gluconeogenesis was assigned to us. Youi should decide which questions are pertinent and most applicable to the assigned pathway.

Your paper should cover the following:

1) Where your pathway located in the cell and what is the main purpose of your pathway
2) Identification of your pathway as either linear, branched, cyclic or spinal
3)How your pathway fits into the overall scheme of metabolism.
4)The class of biomolecuses involved in your pathway (proteins, carbohydrates, lipids or nucleic acids.
5)Where your pathway might be located in an overall map of metabolism
6) Identification of your pathway as anabolic or catabolic.
7) Overall, does your pathway require energy or release energy?
8)Identification of the reactants, key intermediates, and final products in your pathway.
9)Identification of any acidic basic or fundamental groups in each of the reactants, key intermediates, and final products. Are they shown adjusted to pH 7.4? If not, how do u adjust them?
10) Identify any steps which involve phosphorylation/dephosphorylation reactions.
11) Identify any steps which involve hydration/dehydration reactons.
12)Identify any steps which involve hydrolysis reactions.
13) Identify any coupled reactions and what processes are coupled together. a)ocideation/reduction reactions: determine what is being oxidized and what is being reduced b) energy transfer: determine which is exergonic and which is endergonic.

Answer questions below about the metabolic map and additional resources(textbook ‘General, Organic and Biochemistry’ eighth edition and the internet. The number of sources do not matter. Questions just need to be answered from the sources that have the answer. Some questions may be easir to anser than others, but it also depends a lot on a particular pathway that is assigned. Gluconeogenesis was assigned to us. Youi should decide which questions are pertinent and most applicable to the assigned pathway.

Your paper should cover the following:

1) Where your pathway located in the cell and what is the main purpose of your pathway
2) Identification of your pathway as either linear, branched, cyclic or spinal
3)How your pathway fits into the overall scheme of metabolism.
4)The class of biomolecuses involved in your pathway (proteins, carbohydrates, lipids or nucleic acids.
5)Where your pathway might be located in an overall map of metabolism
6) Identification of your pathway as anabolic or catabolic.
7) Overall, does your pathway require energy or release energy?
8)Identification of the reactants, key intermediates, and final products in your pathway.
9)Identification of any acidic basic or fundamental groups in each of the reactants, key intermediates, and final products. Are they shown adjusted to pH 7.4? If not, how do u adjust them?
10) Identify any steps which involve phosphorylation/dephosphorylation reactions.
11) Identify any steps which involve hydration/dehydration reactons.
12)Identify any steps which involve hydrolysis reactions.
13) Identify any coupled reactions and what processes are coupled together. a)ocideation/reduction reactions: determine what is being oxidized and what is being reduced b) energy transfer: determine which is exergonic and which is endergonic.

“I just want to ask if you did find hard to help me with the Norway film could you instead Analyse one Academic book for children ?

The book called Amazing Grace by Mary Hoffman.Caroline Binch

FRAME FOR ANALYSING CHILDREN’S LITERATURE

Sharing literature with young children is about enjoyment and learning, but what are they learning?. Thinking critically about books and ‘reading between the lines’, helps those who work with young children make that sharing as rich as possible.

{or something like that}

Bibliographic details
this section = the same

Summarise the story. e.g.Who are the characters? When and where is the story set? What happens?

What is the underlying idea or message? What would the story encourage children to think about? e.g. right and wrong, conflict, different points of view, identity…

How is the story written and why? e.g. Are sentences short or long, descriptive or action-packed? What sort of vocabulary is used (alliteration, repetition…)? What mood/tone does that create?

Describe and comment on the illustrations
e.g. sensitive, detailed, humorous… How do the illustrations work with the written text? What impact might the pictures have on the reader?

Reflect on why you chose this book and what you think are its strengths (and weaknesses, if any). And how you might use this with young children?”

—

A message from client:
“I just want to ask if you did find hard to help me with the Norway film could you instead Analyse one Academic book for children ?

The book called Amazing Grace by Mary Hoffman.Caroline Binch

FRAME FOR ANALYSING CHILDREN’S LITERATURE

Sharing literature with young children is about enjoyment and learning, but what are they learning?. Thinking critically about books and ‘reading between the lines’, helps those who work with young children make that sharing as rich as possible.

{or something like that}

Bibliographic details
this section = the same

Summarise the story. e.g.Who are the characters? When and where is the story set? What happens?

What is the underlying idea or message? What would the story encourage children to think about? e.g. right and wrong, conflict, different points of view, identity…

How is the story written and why? e.g. Are sentences short or long, descriptive or action-packed? What sort of vocabulary is used (alliteration, repetition…)? What mood/tone does that create?

Describe and comment on the illustrations
e.g. sensitive, detailed, humorous… How do the illustrations work with the written text? What impact might the pictures have on the reader?

Reflect on why you chose this book and what you think are its strengths (and weaknesses, if any). And how you might use this with young children?”

“I just want to ask if you did find hard to help me with the Norway film could you instead Analyse one Academic book for children ?

The book called Amazing Grace by Mary Hoffman.Caroline Binch

FRAME FOR ANALYSING CHILDREN’S LITERATURE

Sharing literature with young children is about enjoyment and learning, but what are they learning?. Thinking critically about books and ‘reading between the lines’, helps those who work with young children make that sharing as rich as possible.

{or something like that}

Bibliographic details
this section = the same

Summarise the story. e.g.Who are the characters? When and where is the story set? What happens?

What is the underlying idea or message? What would the story encourage children to think about? e.g. right and wrong, conflict, different points of view, identity…

How is the story written and why? e.g. Are sentences short or long, descriptive or action-packed? What sort of vocabulary is used (alliteration, repetition…)? What mood/tone does that create?

Describe and comment on the illustrations
e.g. sensitive, detailed, humorous… How do the illustrations work with the written text? What impact might the pictures have on the reader?

Reflect on why you chose this book and what you think are its strengths (and weaknesses, if any). And how you might use this with young children?”

—

A message from client:
“I just want to ask if you did find hard to help me with the Norway film could you instead Analyse one Academic book for children ?

The book called Amazing Grace by Mary Hoffman.Caroline Binch

FRAME FOR ANALYSING CHILDREN’S LITERATURE

Sharing literature with young children is about enjoyment and learning, but what are they learning?. Thinking critically about books and ‘reading between the lines’, helps those who work with young children make that sharing as rich as possible.

{or something like that}

Bibliographic details
this section = the same

Summarise the story. e.g.Who are the characters? When and where is the story set? What happens?

What is the underlying idea or message? What would the story encourage children to think about? e.g. right and wrong, conflict, different points of view, identity…

How is the story written and why? e.g. Are sentences short or long, descriptive or action-packed? What sort of vocabulary is used (alliteration, repetition…)? What mood/tone does that create?

Describe and comment on the illustrations
e.g. sensitive, detailed, humorous… How do the illustrations work with the written text? What impact might the pictures have on the reader?

Reflect on why you chose this book and what you think are its strengths (and weaknesses, if any). And how you might use this with young children?”

“I just want to ask if you did find hard to help me with the Norway film could you instead Analyse one Academic book for children ?

The book called Amazing Grace by Mary Hoffman.Caroline Binch

FRAME FOR ANALYSING CHILDREN’S LITERATURE

Sharing literature with young children is about enjoyment and learning, but what are they learning?. Thinking critically about books and ‘reading between the lines’, helps those who work with young children make that sharing as rich as possible.

{or something like that}

Bibliographic details
this section = the same

Summarise the story. e.g.Who are the characters? When and where is the story set? What happens?

What is the underlying idea or message? What would the story encourage children to think about? e.g. right and wrong, conflict, different points of view, identity…

How is the story written and why? e.g. Are sentences short or long, descriptive or action-packed? What sort of vocabulary is used (alliteration, repetition…)? What mood/tone does that create?

Describe and comment on the illustrations
e.g. sensitive, detailed, humorous… How do the illustrations work with the written text? What impact might the pictures have on the reader?

Reflect on why you chose this book and what you think are its strengths (and weaknesses, if any). And how you might use this with young children?”

—

A message from client:
“I just want to ask if you did find hard to help me with the Norway film could you instead Analyse one Academic book for children ?

The book called Amazing Grace by Mary Hoffman.Caroline Binch

FRAME FOR ANALYSING CHILDREN’S LITERATURE

Sharing literature with young children is about enjoyment and learning, but what are they learning?. Thinking critically about books and ‘reading between the lines’, helps those who work with young children make that sharing as rich as possible.

{or something like that}

Bibliographic details
this section = the same

Summarise the story. e.g.Who are the characters? When and where is the story set? What happens?

What is the underlying idea or message? What would the story encourage children to think about? e.g. right and wrong, conflict, different points of view, identity…

How is the story written and why? e.g. Are sentences short or long, descriptive or action-packed? What sort of vocabulary is used (alliteration, repetition…)? What mood/tone does that create?

Describe and comment on the illustrations
e.g. sensitive, detailed, humorous… How do the illustrations work with the written text? What impact might the pictures have on the reader?

Reflect on why you chose this book and what you think are its strengths (and weaknesses, if any). And how you might use this with young children?”

“I just want to ask if you did find hard to help me with the Norway film could you instead Analyse one Academic book for children ?

The book called Amazing Grace by Mary Hoffman.Caroline Binch

FRAME FOR ANALYSING CHILDREN’S LITERATURE

Sharing literature with young children is about enjoyment and learning, but what are they learning?. Thinking critically about books and ‘reading between the lines’, helps those who work with young children make that sharing as rich as possible.

{or something like that}

Bibliographic details
this section = the same

Summarise the story. e.g.Who are the characters? When and where is the story set? What happens?

What is the underlying idea or message? What would the story encourage children to think about? e.g. right and wrong, conflict, different points of view, identity…

How is the story written and why? e.g. Are sentences short or long, descriptive or action-packed? What sort of vocabulary is used (alliteration, repetition…)? What mood/tone does that create?

Describe and comment on the illustrations
e.g. sensitive, detailed, humorous… How do the illustrations work with the written text? What impact might the pictures have on the reader?

Reflect on why you chose this book and what you think are its strengths (and weaknesses, if any). And how you might use this with young children?”

—

A message from client:
“I just want to ask if you did find hard to help me with the Norway film could you instead Analyse one Academic book for children ?

The book called Amazing Grace by Mary Hoffman.Caroline Binch

FRAME FOR ANALYSING CHILDREN’S LITERATURE

Sharing literature with young children is about enjoyment and learning, but what are they learning?. Thinking critically about books and ‘reading between the lines’, helps those who work with young children make that sharing as rich as possible.

{or something like that}

Bibliographic details
this section = the same

Summarise the story. e.g.Who are the characters? When and where is the story set? What happens?

What is the underlying idea or message? What would the story encourage children to think about? e.g. right and wrong, conflict, different points of view, identity…

How is the story written and why? e.g. Are sentences short or long, descriptive or action-packed? What sort of vocabulary is used (alliteration, repetition…)? What mood/tone does that create?

Describe and comment on the illustrations
e.g. sensitive, detailed, humorous… How do the illustrations work with the written text? What impact might the pictures have on the reader?

Reflect on why you chose this book and what you think are its strengths (and weaknesses, if any). And how you might use this with young children?”